Journal
NATURE GENETICS
Volume 37, Issue 5, Pages 471-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1545
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Funding
- NICHD NIH HHS [P01 HD039691] Funding Source: Medline
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Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a variety of experimental expertise and so is unsuitable for genome-scale analysis. Here we used microarray profiles of mutants as phenotypes for epistasis analysis. Considering genes that regulate activity of protein kinase A in Dictyostelium, we identified known and unknown epistatic relationships and reconstructed a genetic network with microarray phenotypes alone. This work shows that microarray data can provide a uniform, quantitative tool for large-scale genetic network analysis.
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