Journal
EXPERIMENTAL BRAIN RESEARCH
Volume 163, Issue 1, Pages 1-12Publisher
SPRINGER
DOI: 10.1007/s00221-004-2140-6
Keywords
transcranial magnetic stimulation; posterior parietal cortex; attention; neglect; reversible deactivation
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Funding
- NCRR NIH HHS [K24 RR018875] Funding Source: Medline
- NINDS NIH HHS [NS32137, NS44624, NS47754] Funding Source: Medline
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Transcranial magnetic stimulation (TMS) is increasingly utilized in clinical neurology and neuroscience. However, detailed knowledge of the impact and specificity of the effects of TMS on brain activity remains unresolved. We have used C-14-labeled deoxyglucose (C-14-2DG) mapping during repetitive TMS (rTMS) of the posterior and inferior parietal cortex in anesthetized cats to study, with exquisite spatial resolution, the local and distant effects of rTMS on brain activity. High-frequency rTMS decreases metabolic activity at the primary site of stimulation with respect to homologue areas in the unstimulated hemisphere. In addition, rTMS induces specific distant effects on cortical and subcortical regions known to receive substantial efferent projections from the stimulated cortex. The magnitude of this distal impact is correlated with the strength of the anatomical projections. Thus, in the anesthetized animal, the impact of rTMS is upon a distributed network of structures connected to the primary site of application.
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