Journal
IMMUNITY
Volume 22, Issue 5, Pages 561-570Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2005.03.005
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Funding
- NIAID NIH HHS [AI 56172, P01 AI056172-05, R01 AI041576-10, AI 41576, P01 AI056172, R01 AI041576] Funding Source: Medline
- NIDDK NIH HHS [DK 45260, R01 DK045260-15, R01 DK045260] Funding Source: Medline
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Costimulatory signals from dendritic cells (DCs) are required for naive T cells to respond to antigenic stimulation. To what extent DCs reactivate memory T cells during recall responses is not known. Here, an in vivo depletion system has been used to analyze the role of DCs in reactivating CD8 memory T cells during recall responses to three different microbial infections. We show a profound decrease in the numbers of responding memory CD8 T cells in both lymphoid and nonlymphoid tissues during the recall responses to infection with vesicular stomatitis virus, Listeria monocytogenes (Lm), or influenza virus. These data show that interaction with DCs is a major mechanism driving T cell reactivation in vivo, even during a tissue-specific infection of the respiratory tract.
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