Journal
MAGNETIC RESONANCE IMAGING
Volume 23, Issue 4, Pages 591-599Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2005.02.006
Keywords
MRI; breast tissue; fat; parenchyma; estimation
Funding
- NCI NIH HHS [CA82707-01, CA090699-0182] Funding Source: Medline
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Mammographic breast density has been correlated with breast cancer risk. Estimation of the volumettic composition of breast tissue using three-dimensional MRI has been proposed, but accuracy depends upon the estimation methods employed. The use of segmentation based on T, relaxation rates allows quantitative estimates of fat and parenchyma volume, but is limited by partial volume effects. An investigation employing phantom breast tissue composed of various combinations of chicken breast (to represent parenchyma) and cooking fats was carried out to elucidate the factors that influence MRI T, histograms. Using the phantoms, T, histograms and their known fat and parenchyma composition, a logistic distribution function was derived to describe the apportioning of the T, histogram to fat and parenchyma. This function and T, histograms were then used to predict the fat and parenchyma content of breasts from 14 women. Using this method, the composition of the breast tissue in the study population was as follows: fat 69.9 +/- 22.9% and parenchyma 30.1 +/- 22.9%. (c) 2005 Elsevier Inc. All rights reserved.
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