Neurotoxicity of exposures to aluminium welding fumes in the truck trailer construction industry

The aim of the study was to examine aluminium welders for central nervous changes due to the exposure to aluminium containing welding fumes. A group of 44 aluminium welders in the train body and truck trailer construction industry (mean age: 43 years) with an average of 11.4 years of occupational exposure to aluminium welding fumes and a control group of 37 production workers (mean age: 40 years) of the same plants participated in this longitudinal study. Medical and neuropsychological examinations were performed in 1999 and 2001. Performance was measured with computerised (EURO-NES, motor performance, simple reaction time) and non-computerised test systems (verbal intelligence, standard progressive matrices, trail making, block design) and symptoms with a modified version of the questionnaire Q16. Data was analysed by multivariate analysis of variance including age, education, and alcohol marker as covariates (MANCOVA). The pre-/postshift average Al-urine concentrations of welders were in the range of 130-153 μ g/l. Welders showed significantly poorer performance in symbol-digit substitution, block design, and to some extent in switching attention. However, motor performance and other measures did not differ between welders and controls. Summing up, the results give no clear hints on neurological changes in Al-welders. © 2004 Elsevier B.V. All rights reserved.