Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 201, Issue 9, Pages 1447-1457Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20041204
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Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8(+) T cells requires CCR7. In contrast, MHC class Ib-restricted CD8(+) T cells and MHC class II-restricted CD4(+) T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8(+) T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
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