Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 18, Pages 6467-6472Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0501912102
Keywords
allergy; asthma; autoimmunity; cytokines; immune response
Categories
Funding
- NCI NIH HHS [CA72074, R01 CA072074] Funding Source: Medline
- NHLBI NIH HHS [P01 HL067674, P50 HL067674, HL67674] Funding Source: Medline
- NIAID NIH HHS [R01 AI023990, AI23990, R37 AI023990] Funding Source: Medline
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Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by Fc epsilon RI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.
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