Journal
ONCOGENE
Volume 24, Issue 20, Pages 3268-3273Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208448
Keywords
caspase; SUMO; nuclear localization; apoptosis; human
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The cysteine protease caspase-8 plays a pivotal role in the initiation of different apoptotic pathways and controls the maturation and differentiation of various cell types including neurons, fibroblasts and lymphocytes. Specific substrates of caspase-8 are present in both the cytoplasm and the nucleus, which may determine the ultimate biological effect of caspase-8. However, the mechanisms regulating the cellular localization of caspase-8 are still unknown. We show here that, in contrast to other caspases such as caspase-9 and -3, caspase-8 can be sumoylated at lysine 156. This sumoylation (i) is associated with the nuclear localization of caspase-8 and (ii) did not impair caspase-8 activation.
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