Journal
APPLIED ENTOMOLOGY AND ZOOLOGY
Volume 46, Issue 4, Pages 533-543Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s13355-011-0074-6
Keywords
Cytochrome P450 monooxygenase; Prothoracic gland; Bombyx mori; Drosophila melanogaster
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of the Japanese Government
- JSPS [19380034]
- Program for Promotion of Basic Research Activities for Innovative Biosciences
- Grants-in-Aid for Scientific Research [19380034] Funding Source: KAKEN
Ask authors/readers for more resources
Here we describe the expression profiles of the cytochrome P450 monooxygenase gene Cyp4g1 in the fruit fly, Drosophila melanogaster Meigen, and its homolog in the silkworm, Bombyx mori L. We identified Cyp4g1 by a microarray analysis to examine the expression levels of 86 predicted D. melanogaster P450 genes in the ring gland that contains the prothoracic gland (PG), an endocrine organ responsible for synthesizing ecdysteroids. B. mori Cyp4g25 is a closely related homolog of D. melanogaster Cyp4g1 and is also expressed in the PG. A developmental expression pattern of Cyp4g25 in the PG is positively correlated with a fluctuation in hemolymph ecdysteroid titer in the late stage of the final instar. Moreover, the expression of Cyp4g25 in cultured PGs is significantly induced by the addition of prothoracicotropic hormone (PTTH), a neuropeptide hormone that stimulates the synthesis and release of ecdysone. We propose that Cyp4g1 and Cyp4g25 are the candidates that play a role in regulating PG function and control ecdysteroid production and/or metabolism during insect development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available