Journal
JOURNAL OF CELL BIOLOGY
Volume 169, Issue 3, Pages 391-397Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200411089
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Funding
- NIGMS NIH HHS [P50 GM066050, GM07270, GM65061, GM69429, F31 GM065061, GM066050, T32 GM007270, R01 GM069429] Funding Source: Medline
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MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-terminal tail of MCAK. Tip tracking is not essential for MCAK's MT-depolymerizing activity. We propose that tip tracking is a mechanism by which MCAK is preferentially localized to regions of the cell that modulate the plus ends of MTs.
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