Journal
DRUG AND ALCOHOL DEPENDENCE
Volume 78, Issue 2, Pages 135-140Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2004.10.006
Keywords
cocaine; MDMA; drug abuse; reinforcing efficacy; rhesus monkey
Categories
Funding
- NIDA NIH HHS [DA-06634, DA-05934] Funding Source: Medline
Ask authors/readers for more resources
The purpose of the present study was to compare the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to cocaine. Rhesus monkeys (n = 4) responded under a within-session, exponentially increasing, progressive-ratio (PR) schedule of cocaine reinforcement. Breaking point (BP) for the PR schedule was defined as the final response requirement completed before 2 h had elapsed without an injection delivered. Saline and doses of cocaine (0.003-0.3 mg/kg/injection) and MDMA (0.01-0.56 mg/kg/injection) were substituted for the training dose of cocaine for at least five consecutive sessions. Both cocaine and MDMA functioned as reinforcers, but self-administration of MDMA occurred at fewer doses and a significantly lower peak BP was obtained for MDMA. These data demonstrate that MDMA functions as a reinforcer, although its reinforcing efficacy appears to be less than that of cocaine. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available