4.4 Article

One-pot synthesis of substituted catechols from the corresponding phenols

Journal

TETRAHEDRON LETTERS
Volume 46, Issue 19, Pages 3357-3358

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.03.082

Keywords

ortho-formylation of phenols; Dakin reaction; substituted catechols

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Pheriols are converted to salicylaldehydes with paraformaldehyde, MgCl2-Et3N in THF, and when subsequently treated with aqueous NaOH and H2O2 afford the corresponding catechols. The sequence is conveniently carried out as a one-pot procedure. (c) 2005 Elsevier Ltd. All rights reserved.

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