Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 28, Pages 15148-15153Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03866
Keywords
albumin; cell-penetrating peptide; self-assembly; nanoparticles; drug delivery; blood-brain barrier
Funding
- National Natural Science Foundation of China [21274113]
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Drug delivery has become an important strategy for improving the chemotherapy efficiency. Here we developed a multifunctionalized nanosized albumin-based drug-delivery system with tumor-targeting, cell-penetrating, and endolysosomal pH-responsive properties. cRGD-BSA/KALA/DOX nanoparticles were fabricated by self-assembly through electrostatic interaction between cell-penetrating peptide KALA and cRGD-BSA, with cRGD as a tumor-targeting ligand. Under endosomal/lysosomal acidic conditions, the changes in the electric charges of cRGD-BSA and KALA led to the disassembly of the nanoparticles to accelerate intracellular drug release. cRGD-BSA/KALA/DOX nanoparticles showed an enhanced inhibitory effect in the growth of alpha(v)beta(3)-integrin-overexpressed tumor cells, indicating promising application in cancer treatments.
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