Journal
SCIENCE
Volume 308, Issue 5724, Pages 1043-1045Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1108750
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL059598, HL75029, HL59598, R01 HL075029] Funding Source: Medline
- NIA NIH HHS [AG18200, P01 AG011412, AG11412, R01 AG018200] Funding Source: Medline
- NIDDK NIH HHS [DK26356, K08 DK002675, R01 DK026356, DK02675] Funding Source: Medline
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The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important rote in mammalian energy balance.
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