On the mechanism of solubilization of drugs in the presence of poorly soluble additives

A model is proposed which describes the solubilization of a poorly Soluble drug in the presence of an insoluble excipient which forms an easily soluble compound with the drug. For sulfathiazole-calcium carbonate system as an example, it is demonstrated using sulfathiazole single crystals and powdered samples that the presence of insoluble additive causes an increase in dissolution rate and solubility of the drug. (c) 2005 Elsevier B.V. All rights reserved.