Journal
JOURNAL OF APPLIED PHYSICS
Volume 97, Issue 10, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.1853694
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Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size. (c) 2005 American Institute of Physics.
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