Magnetic resonance imaging and low back pain in adults: A diagnostic imaging study of 40-year-old men and women

Study Design. Cross-sectional cohort study of a general population. Objective. To investigate abnormal lumbar spine magnetic resonance imaging (MRI) findings, and their prevalence and associations with low back pain (LBP). Summary of Background Data. The clinical relevance of various abnormal findings in the lumbar spine is unclear. Distinguishing between inevitable age-related findings and degenerative findings with deleterious consequences is a challenge. Methods. Lumbar spine MRI was obtained in 412, 40-year-old individuals. Predefined abnormal MRI findings were interpreted without any knowledge of patient symptoms. Associations between MRI abnormalities and LBP were calculated using odds ratios. The overall picture of each MRI finding was established on the basis of the frequencies, diagnostic values, and the strength and consistency of associations. Results. Most abnormal MRI findings were found at the lowest lumbar levels. Irregular nucleus shape and reduced disc height were common (> 50% of individuals). Relatively common (25% to 50%) were hypointense disc signal, anular tears, high intensity zones, disc protrusions, endplate changes, zygapophyseal joint degeneration, asymmetry, and foraminal stenosis. Nerve root compromise, Modic changes, central spinal stenosis, and anterolisthesis/retrolisthesis were rare (< 25%). Most strongly associated with LBP were Modic changes and anterolisthesis (odds ratios > 4). Significantly positive associations with all LBP variables were seen for hypointense disc signals, reduced disc height, and Modic changes. All disc abnormalities except protrusion were moderately associated with LBP during the past year. Conclusion. Most degenerative disc abnormalities were moderately associated with LBP. The strongest associations were noted for Modic changes and anterolisthesis. Further studies are needed to define clinical relevance.