Journal
JOURNAL OF IMMUNOLOGY
Volume 174, Issue 10, Pages 6045-6053Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.10.6045
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- NIAID NIH HHS [N01-AI40009] Funding Source: Medline
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delta gamma T cells recognize unprocessed or non-peptide Ags, respond rapidly to infection, and localize to mucosal surfaces. We have hypothesized that the innate functions of delta gamma T cells may be more similar to those of cells of the myeloid lineage than to other T cells. To begin to test this assumption, we have analyzed the direct response of cultured human and peripheral blood bovine delta gamma T cells to pathogen associated molecular patterns (PAMPs) in the absence of APCs using microarray, real-time RT-PCR, proteome array, and chemotaxis assays. Our results indicate that purified delta gamma T cells respond directly to PAMPs by increasing expression of chemokine and activation-related genes. The response was distinct from that to known delta gamma T cell Ags and different from the response of myeloid cells to PAMPs. In addition, we have analyzed the expression of a variety of PAMP receptors in delta gamma T cells. Freshly purified bovine delta gamma T cells responded more robustly to PAMPs than did cultured human cells and expressed measurable mRNA encoding a variety of PAMP receptors. Our results suggest that rapid response to PAMPs through the expression of PAMP receptors may be another innate role of delta gamma T cells.
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