Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1734, Issue 2, Pages 143-151Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2005.03.003
Keywords
lipid; lipoprotein; genetic; exercise; risk factor
Funding
- NIA NIH HHS [AG00268, AG15389, AG17474, 2P60 AG12583, AG023464, AG022791] Funding Source: Medline
- NIDDK NIH HHS [DK46204] Funding Source: Medline
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Background: High-density lipoprotein cholesterol (HDL-C) and its subfractions are modifiable with exercise training and these responses are heritable. The interleukin-6 (IL6)-174G/C polymorphism may be associated with HDL-C levels. We hypothesized that the IL6-174G/C polymorphism would be associated with plasma HDL-C response to exercise training. Methods and results: Sixty-five 50- to 75-year-olds on a standardized diet were studied before and after 24 weeks of aerobic exercise training. Significant differences existed among genotype groups for change with exercise training in HDL-C, HDL3-C, integrated HDL4,5NMR-C, and HDLsize. The CC genotype group increased HDL-C more than the GG (7.0 +/- 1.3 v. 1.0 +/- 1.1 mg/dL, p=0.001) and GC groups (3.3 +/- 0.9 mg/dL, p=0.02); for HDL3-C, the CC group increased more than the GG (6.1 +/- 1.0 v. 0.9 +/- 0.9, mg/dL p <0.001) and GC groups (2.5 +/- 0.7 mg/dL,p=0.006). Integrated HDL4,5NMR-C increased more in the CC than GG group (6.5 +/- 1.6 mg/dL v. 1.0 +/- 1.3 mg/dL, p=0.01), as did HDLsize compared to the GG (CC: 0.3 +/- 0.1 v. GG: 0.1 +/- 0.1 nm, p=0.02) and GC (0.0 +/- 0.0 nm, p=0.007) groups. Conclusions: IL6 genotype is associated with HDL-C response to exercise training. (C) 2005 Elsevier B.V. All rights reserved.
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