Journal
BIOLOGICAL PSYCHIATRY
Volume 57, Issue 10, Pages 1209-1211Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.02.007
Keywords
continuous performance test; human; impulsivity; norepinephrine; yohimbine
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Funding
- NIAAA NIH HHS [R01 AA12046] Funding Source: Medline
- NIDA NIH HHS [R01 DA08425, K02 DA00403] Funding Source: Medline
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Background: State-dependent changes in impulsivity many be related to norepinephrine. To examine possible relationships between nompinephrine and acute changes in impulsivity we measured effects of yohimbine, which increases norepinephrine release by blocking alpha-2 noradrenegic receptors, on laboratory-measured impulsivity in healthy subjects without psychiatric or substance-use disorders. Methods. Impulsivity was assessed using The Immediate and Delayed Memory Tasks (IMT-DMT), derived from the Continuous Performance Test, before and after placebo or-two doses of yohimhine, given 4 days apart. Blood pressure was monitored, and psychiatric symptoms were measured using self-rated visual analog scales. Results: Yohimbine was associated with a dose-relaled increase in impulsive IMT commission errors, with an increase of > 50% relative to baseline at the higher close. The activation factor of the Internal State Scale was increased at the same close. Conclusions: These results are consistent with increased impulsivity in normal subjects given yohimhine, possibly related to increased norepinephrine.
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