Journal
OPTICS LETTERS
Volume 30, Issue 10, Pages 1159-1161Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.30.001159
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Funding
- NCI NIH HHS [R01 CA095604, R01 CA095604-05A2] Funding Source: Medline
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A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μ m of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed. © 2005 Optical Society of America.
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