Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 10, Pages 2583-2585Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.03.043
Keywords
iridium catalyst; intramolecular Tischenko reaction; isocoumarin; ketoaldehyde; oxidative lactonization
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Two new cyclizations of ketoaldehydes have been developed using an Ir-ligand bifunctional catalyst. Oxidative lactonization of sigma-ketoaldehydes proceeded smoothly at room temperature to give coumarin derivatives in excellent yields. Intramolecular Tishchenko reaction of sigma-ketoaldehydes afforded 3,4-dihydroisocoumarins in good yields. (c) 2005 Elsevier Ltd. All rights reserved.
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