Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 515, Issue 1-3, Pages 90-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.03.044
Keywords
nicotine; withdrawal; hyperalgesia; knockout
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Funding
- NIDA NIH HHS [DA-07027, DA-05274] Funding Source: Medline
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Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized a, nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 mu g/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia (tail-flick and hot-plate) and spontaneous activity following nicotine cessation. Nicotine withdrawal produced increased somatic signs in both strains and hyperalgesia in wild-type, but not in knockout animals. These results indicate that the alpha nicotinic receptor subunit may mediate some aspects of nicotine dependence, (c) 2005 Elsevier B.V All fights reserved.
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