Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 10, Pages 2571-2574Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.03.046
Keywords
gemcitabine; lipid-nucleoside conjugate; cardiolipin; prodrug
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A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gerrizar (R). (c) 2005 Elsevier Ltd. All rights reserved.
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