Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 20, Pages 7332-7337Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0502757102
Keywords
evolution; horizontal gene transfer; microbial speciation; recombination
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We model the competition between homologous recombination and point mutation in microbial genomes, and present evidence for two distinct phases, one uniform, the other genetically diverse. Depending on the specifics of homologous recombination, we find that global sequence divergence can be mediated by fronts propagating along the genome, whose characteristic signature on genome structure is elucidated, and apparently observed in closely related Bacillus strains. Front propagation provides an emergent, generic mechanism for microbial speciation, and suggests a classification of microorganisms on the basis of their propensity to support propagating fronts.
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