4.8 Article

The use of oscillatory signals in the study of genetic networks

Publisher

NATL ACAD SCIENCES
DOI: 10.1073/pnas.0403790102

Keywords

systems biology; synthetic biology; stochastic processes

Funding

  1. NHGRI NIH HHS [R01 HG002341, 1R01HG02341] Funding Source: Medline

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The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.

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