Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 20, Pages 7063-7068Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0403790102
Keywords
systems biology; synthetic biology; stochastic processes
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Funding
- NHGRI NIH HHS [R01 HG002341, 1R01HG02341] Funding Source: Medline
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The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.
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