Journal
BRAIN RESEARCH
Volume 1044, Issue 1, Pages 127-131Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.03.011
Keywords
peptide YY; glucagon-like peptide-1; appetite; vagus nerve; brainstein; hypothalamus
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Funding
- Wellcome Trust Funding Source: Medline
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The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have, shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurotics are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY3-36 and GLP-1 on food intake. (c) 2005 Elsevier B.V. All rights reserved.
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