Journal
NEURON
Volume 46, Issue 4, Pages 671-679Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2005.04.021
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We showed how cognitive, semantic information modulates olfactory representations in the brain by providing a visual word descriptor, cheddar cheese or body odor, during the delivery of a test odor (isovaleric acid with cheddar cheese flavor) and also during the delivery of clean air. Clean air labeled air was used as a control. Subjects rated the affective value of the test odor as significantly more unpleasant when labeled body odor than when labeled cheddar cheese. In an event-related fMRI design, we showed that the rostral anterior cingulate cortex (ACC)/medial orbitofrontal cortex (OFC) was significantly more activated by the test stimulus and by clean air when labeled cheddar cheese than when labeled body odor, and the activations were correlated with the pleasantness ratings. This cognitive modulation was also found for the test odor (but not for the clean air) in the amygdala bilaterally.
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