Journal
FEBS LETTERS
Volume 579, Issue 13, Pages 2759-2766Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.094
Keywords
Alzheimer disease; blood antioxidant power; Cathepsin D; Cystatin C; beta-amyloid precursor protein; platelet; peripheral blood lymphocyte
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Markers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty-three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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