Journal
FEBS LETTERS
Volume 579, Issue 13, Pages 2833-2841Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.099
Keywords
tumour; immune response; reactive oxygen species; nitric oxide
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Induction of apoptosis in a lymphoma cell line using immune cell-conditioned medium, etoposide or an nitric oxide (NO) donor, resulted in the production of reactive oxygen species (ROS). Agents that inhibited NO production or scavenged ROS or species formed by reaction of NO with ROS, protected the cells from apoptosis. These data support the suggestion that immune rejection of an immunogenic derivative of this lymphoma in vivo involves the induced synthesis of both NO and ROS by the tumour cells. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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