Journal
TETRAHEDRON
Volume 61, Issue 22, Pages 5209-5217Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.03.082
Keywords
acetals; micro reactor; deprotection
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Funding
- Engineering and Physical Sciences Research Council [GR/S34106/01] Funding Source: researchfish
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Through incorporating a series of polymer-supported acid catalysts into a miniaturised EOF-based flow reactor, we demonstrate a clean and efficient technique for the protection of aldehydes as their respective dimethyl acetal. In addition, we also report the acid catalysed deacetalisation of 11 dimethyl acetals to their respective aldehyde. In all cases, the compounds described are obtained in high yield (> 95%) and excellent purity (> 99%) without the need for further product purification. (c) 2005 Elsevier Ltd. All rights reserved.
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