Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 139, Issue 1, Pages 1-7Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2004.08.004
Keywords
brain; depression; geriatrics; medical comorbidity; magnetic resonance imaging
Categories
Funding
- NIMH NIH HHS [R01 MH 54846, P50 MH 60451, K23 MH 65939] Funding Source: Medline
Ask authors/readers for more resources
Hyperintense lesions in both white matter and gray matter on T2-weighted magnetic resonance imaging (MRI) are associated with late-life depression. This large study examined differences in gray and white matter lesion volumes on brain MRl between 253 elderly depressed and 146 control subjects. White matter and gray matter lesion volumes were measured in each hemisphere using a semi-automated segmentation process and compared against depression status. Depressed subjects exhibited significantly greater total white matter (mean 7.22 ml) and gray matter (mean 0.30 ml) lesion volumes in both hemispheres than did control subjects (mean 4.87 ml in white matter and 0.18 ml in gray matter). This difference remained statistically significant even after controlling for confounders such as age, sex, race and reports of hypertension, diabetes and heart disease. Patients with late-life depression have larger white matter lesion and gray matter lesion volumes than do control subjects. Future research should combine similar volumetric techniques with methods of identifying the location of lesions specific to late-life depression. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available