Journal
PROSTATE CANCER AND PROSTATIC DISEASES
Volume 8, Issue 2, Pages 163-166Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.pcan.4500788
Keywords
PSA; clinical recurrence
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Detectable prostate-specific antigen levels (PSA) following radical prostatectomy ( RP) are believed to represent treatment failure. In this retrospective review, we characterize long-term PSA outcomes following RP ( n = 204) in a nonreferral hospital performed between 1984 and 1994. With an average follow-up of 10 y, 90 (44%) patients developed a PSA recurrence: 15 (17%) died of prostate cancer despite hormonal intervention, 39 (43%) responded to hormonal therapy with stable remission and 36 (40%) were observed without intervention. Following RP many patients may have a detectable PSA that does not require treatment. PSA doubling time ( <12 months) was the best predictor of disease progression.
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