Journal
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Volume 24, Issue 6, Pages 777-780Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2004.02.020
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When right ventricular failure develops secondary to primary pulmonary hypertension, right-left ventricular interaction may lead to severe impairment of left ventricular function. In such cases, many experts favor combined heart-lung transplantation by fear that the left ventricle may not recover after transplantation of the lungs alone. We report a case of primary pulmonary hypertension with severely diminished right and left ventricular function. The patient was rendered amenable to isolated pulmonary transplantation with the endothelin-receptor antagonist bosentan. The medication improved right and left ventricular function to the point that heart transplantation no longer appeared necessary. After double-lung transplantation the patient's cardiac function made a full recovery. This approach might be particularly welcome considering both the current donor organ shortage and the limited number of surgical teams with expertise in heart-lung transplantation. (c) 2005 by the International Society for Heart and Lung Transplantation.
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