Journal
DEVELOPMENT
Volume 132, Issue 12, Pages 2907-2916Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.01848
Keywords
hydra; head organizer; canonical Wnt pathway
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Stabilization of beta-catenin by inhibiting the activity of glycogen synthase kinase-3 beta has been shown to initiate axis formation or axial patterning processes in many bilaterians. In hydra, the head organizer is located in the hypostome, the apical portion of the head. Treatment of hydra with alsterpaullone, a specific inhibitor of glycogen synthase kinase-3 beta, results in the body column acquiring characteristics of the head organizer, as measured by transplantation experiments, and by the expression of genes associated with the head organizer. Hence, the role of the canonical Wnt pathway for the initiation of axis formation was established early in metazoan evolution.
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