Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 20, Issue 6, Pages 1251-1253Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfh749
Keywords
chemotherapy; Freelite assay; light-chain deposition disease; nephrotic syndrome
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A 59-year-old male was diagnosed with nephrotic syndrome secondary to light-chain deposition disease. There was no other evidence of a B cell clonal disorder or amyloidosis; circulating free light chains were identified using a new immunoassay (Freelite) and used to monitor disease progression. Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. This case demonstrates a new tool in monitoring light-chain deposition disease in the kidney.
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