Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 135, Issue 2, Pages 147-156Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2005.02.010
Keywords
lecithin; glyceryl tripalmitate; phase behavior; warm microemulsion; NMR PGSE
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Warm microemulsions based on lipids characterized by a melting point over 50 degrees C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water(W)/tripalmitin (TP) system at 70 degrees C. The study has been carried out at LCT/B=1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT+B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of H-1 NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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