Journal
BIOCHEMISTRY AND CELL BIOLOGY
Volume 83, Issue 3, Pages 322-331Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/o05-040
Keywords
Polycomb; Trithorax; RNAi; cell memory; noncoding RNA; epigenome
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Funding
- Telethon [TCP00094] Funding Source: Medline
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Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.
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