Journal
ENDOCRINE REVIEWS
Volume 26, Issue 4, Pages 479-503Publisher
ENDOCRINE SOC
DOI: 10.1210/er.2004-0010
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Funding
- FIC NIH HHS [TW/HD-00668] Funding Source: Medline
- NCRR NIH HHS [RR-00163] Funding Source: Medline
- NICHD NIH HHS [HD-19899, HD-18185] Funding Source: Medline
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Receptors, hormones, enzymes, ion channels, and structural components of the cell are created by the act of protein synthesis. Synthesis alone is insufficient for proper function, of course; for a cell to operate effectively, its components must be correctly compartmentalized. The mechanism by which proteins maintain the fidelity of localization warrants attention in light of the large number of different molecules that must be routed to distinct subcellular loci, the potential for error, and resultant disease. This review summarizes diseases known to have etiologies based on defective protein folding or failure of the cell's quality control apparatus and presents approaches for therapeutic intervention.
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