Journal
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Volume 27, Issue 1, Pages 119-127Publisher
SPRINGER
DOI: 10.1007/s00281-005-0200-z
Keywords
CD8(+)T cell function; tumor immunology; T cell assays; effector cytokines; cellular microarray
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Advances in molecular and cellular biology have illustrated both the flexibility and complexity involved in host immune responses. Understanding this response is vital to the further development of therapeutic strategies that involve manipulation of the cellular immune response to target tumors. Mobilized, tumor antigen-specific T cells, the core for most immunotherapeutic strategies, are highly regulated, and capable of a wide spectrum of functional responses. Due to differences in murine and human immunity, broad-scale immune monitoring, particularly high-throughput ex vivo analysis of human immune responses, promises to determine what comprises an effective immunotherapy. Such understanding will lead to more sophisticated clinical trials, earlier determination of efficacy and individualized protocols.
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