Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 17, Issue 3, Pages 298-302Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.04.007
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Funding
- NIGMS NIH HHS [T32 GM007337] Funding Source: Medline
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The germinal center (GC) is an important anatomical site for the development of high affinity antibodies during T-cell dependent B cell responses. Although the importance of the GC response to humoral immunity is well known, much remains to be elucidated about GC induction, maintenance and regulation. Recent studies examining the GC response in mice have identified key molecules expressed on follicular dendritic cells that support the differentiation of GC B cells, revealed essential chemokines that direct the organization of light and dark zones, and demonstrated potentially novel roles for TNF family members in the differentiation of GC B cells.
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