Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 17, Issue 3, Pages 332-339Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.04.004
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Funding
- NIBIB NIH HHS [P20 EB4930, P20 EB004930, EB 2060, R01 EB002060] Funding Source: Medline
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Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.
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