Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 17, Issue 3, Pages 259-266Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.04.002
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- Wellcome Trust Funding Source: Medline
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The complexity of the Notch signalling pathway has impeded progress in understanding its precise role in differentiation processes of the mature peripheral immune system. Nevertheless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining the mechanisms by which this is achieved remains a challenge. How the innate-adaptive interface and interactions between lymphocytes can be affected, together with the potential of this pathway for therapeutic intervention remain important and stimulating issues.
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