Journal
CANCER CELL
Volume 7, Issue 6, Pages 505-512Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2005.05.025
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Funding
- NCI NIH HHS [R01 CA 094150, R01 CA094150] Funding Source: Medline
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Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy.
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