Journal
INFECTION AND IMMUNITY
Volume 73, Issue 6, Pages 3745-3748Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.6.3745-3748.2005
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During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-a production in S. pyogenes infection.
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