Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 16, Issue 3, Pages 407-421Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2005.02.012
Keywords
retina; cerebellum; cortex; Rb; cyclin D
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The retina is one of the best-characterized regions of the central nervous system (CNS) and has served as a model for many of the principles that now form the foundation for CNS development. In the past several years, a number of advances have been made in our understanding of the coordination of proliferation and cell fate specification during retinal development. In this review, we will draw on findings from studies of the retina and highlight similarities and differences in other regions in the CNS, namely the cerebellum and cortex. We will present a framework in which to pose challenges and outstanding questions for future studies on the coordination of proliferation and cell fate specification in the developing CNS. (c) 2005 Elsevier Ltd. All rights reserved.
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