Journal
NEUROBIOLOGY OF AGING
Volume 26, Issue 6, Pages 785-788Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.08.002
Keywords
Alzheimer's disease; beta amyloid-protein; presenilin-1; age of onset; pathogenesis
Categories
Ask authors/readers for more resources
More than 130 known mutations in the presenilin-1 (PS1) gene result in familial Alzheimer's disease (FAD) with a mutation specific age of disease onset. These mutations increase amyloid beta 42 (A beta 42) levels, and this increase has been validated in recent years as one pathogenic factor in FAD. However, further malfunctions of mutant presenilin-1 are discussed as well. In order to assess the weight of A beta 42 regarding the pathogenesis of FAD, we expressed mutant forms of PS1 (30-65 years onset age) in COS-7 cells and analyzed amyloid beta levels by a novel ELISA. We found a strong correlation (r = 0.98; p < 0.00 1) between the A beta 40/42-ratio and mean age of disease onset indicating a substantial extent of A beta 42 contribution to FAD pathology. Our data strongly suggest that A beta 42 is the decisive factor for age of onset in FAD. (c) 2004 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available