Journal
GLIA
Volume 50, Issue 4, Pages 351-361Publisher
WILEY
DOI: 10.1002/glia.20213
Keywords
astrocyte; gap junctions; metabolism; connexin43; bystander effect; hypoxia-ischemia
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Funding
- NINDS NIH HHS [NIH R21 NS42916, R01 NS042152-01] Funding Source: Medline
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Our knowledge of astroglia and their physiological and pathophysiological role(s) in the central nervous system (CNS) has grown during the past decade, revealing a complex picture. It is becoming increasingly clear that glia play a significant role in the homeostasis and function of the CNS and that neurons should no longer be considered the only cell type that responds, both rapidly and slowly, to electrochemical activity. We discuss recent advances in the field with an emphasis on the impact of hypoxia and ischemia on astrocytic metabolism and the functional relationship between glucose metabolism and gap junctions in astrocytes. We also address the controversy over whether astrocytic gap junctions mediate protection or killing of neurons during or after hypoxic or ischemic insults. (c) 2005 Wiley-Liss, Inc.
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