Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 162, Issue 6, Pages 1211-1213Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.162.6.1211
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Funding
- NCRR NIH HHS [RR-13642, RR-12619] Funding Source: Medline
- NIDA NIH HHS [DA-13054] Funding Source: Medline
- NIMH NIH HHS [K24 MH-01848] Funding Source: Medline
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Objective: This study sought to investigate neural activity in the amygdala during episodes of mania. Method: Nine manic subjects and nine healthy comparison subjects underwent functional magnetic resonance imaging ( fMRI) while performing a neuropsychological paradigm known to activate the amygdala. Subjects viewed faces displaying affect ( experimental task) and geometric forms (control task) and matched them to one of two simultaneously presented similar images. Results: Manic subjects had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbitofrontal cortex relative to the comparison subjects. Conclusions: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.
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