Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 6, Pages 1408-1418Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI24756
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Funding
- NHGRI NIH HHS [K01-HG00055, K01 HG000055] Funding Source: Medline
- NIMH NIH HHS [MH44292, R01 MH044292, R37 MH044292] Funding Source: Medline
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The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.
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